A new research suggests that adding coronary artery calcium scores (CACS) to traditional risk factors for coronary heart disease (CHD) events significantly improves predictions of risk, and results in more individuals being placed in the highest and lowest risk categories.
Tamar S. Polonsky, from the Northwestern University Feinberg School of Medicine, Chicago, and colleagues conducted the study to determine whether adding CACS to a prediction model based on traditional risk factors improves classification of risk.
AdvertisementCACS was measured by computed tomography (a type of imaging method) in 6,814 participants from the Multi-Ethnic Study of Atherosclerosis (MESA), a population-based cohort without known cardiovascular disease.
Recruitment of participants began in July 2000, with follow-up through May 2008. Five-year risk estimates for new CHD were categorized as 0 percent to less than 3 percent, 3 percent to less than 10 percent, and 10 percent or more using hazards models.
Model 1 incorporated age, race/ethnicity, sex, tobacco use, antihypertensive medication use, systolic blood pressure and total and high-density lipoprotein cholesterol measurements.
Model 2 used these risk factors plus CACS. The researchers calculated the net reclassification improvement using model 2 vs. model 1.
Among a final group of 5,878 individuals, there were 209 CHD events during a median (midpoint) follow-up of 5.8 years, of which 122 were major events (heart attack, death from CHD, or resuscitated cardiac arrest).
The researchers found that model 2 resulted in significant improvements in risk prediction compared with model 1. In model 1, 69 percent of the cohort was classified in the highest or lowest risk categories compared with 77 percent in model 2.
With the addition of CACS to the model, an additional 23 percent of those who experienced events were reclassified as high risk and an additional 13 percent of those who did not experience events were reclassified as low risk.
Among intermediate-risk individuals, 16 percent were reclassified as high risk while 39 percent were classified as low risk.
"The results of this study demonstrate that when CACS is added to traditional risk factors, it results in a significant improvement in the classification of risk for the prediction of CHD events in an asymptomatic population-based sample of men and women drawn from 4 U.S. racial/ethnic groups," the authors said.
"Incorporation of an individual's CACS leads to a more refined estimation of future risk of CHD events than traditional risk factors alone," the authors added.
The study has been published in the April 28 issue of JAMA.