Compound in BP Drugs may Prevent Cognition Loss Brain Tumor Patients

by Sreeraman on  February 20, 2009 at 3:46 PM Drug News
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Researchers from at Wake Forest University Baptist Medical Centre have found that a compound used in blood pressure medication may help prevent cognitive loss after radiation therapy in brain tumor patients.

In the study conducted using a rat model, the researchers assumed that that a compound similar to the anti-hypertensive drug losartan can prevent the cognition loss that has been closely-associated with radiation therapy for brain tumor treatment.

The researchers hope that the same theory could easily be applied in a human clinical trial setting because the drug used has a long-established safety profile in patients who have taken it to treat high blood pressure.

"We need to kill cancer cells but also prevent or reduce treatment-related side effects," said Mike E. Robbins, Ph.D., a professor in the department of radiation oncology at the Brain Tumor Centre of Excellence, part of Wake Forest University School of Medicine.

"One very interesting feature of this compound is that it has never shown any pro-tumor effects. If anything, it appears to have anti-tumor properties.

"We're very close to having a compound that will protect the normal brain from cognitive injury as a result of radiation and, at the same time, we may very well increase the likelihood of one day curing brain cancer patients of their tumors," he added.

Previous studies had shown that radiation may lead to the overproduction of angiotensin II (Ang II), a peptide that has been associated with decline of brain function.

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