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Common Nutritional Supplement Effective Against Primary Liver Cancer
S-adenosylmethionine or SAMe was found to be effective in preventing the formation of HCC in rats, however, high enough levels of SAMe were not attainable to successfully treat established HCC. uring the study, researchers led by Dr Shelly Lu, of the Keck School of Medicine at the University of Southern California, injected H4IIE cells into rats and found a 1cm tumour developed in the liver two weeks after injection.
A regimen of IV SAMe was started one day after injecting the cells and continued for ten days.
"Treatment with IV SAMe by continuous infusion significantly reduced the tumour size and significantly prevented tumour development after 11 days," said researchers.
Researchers found that if SAMe infusion was started after sizable tumours had already formed it failed to reduce the rate of tumour growth after 24 days of treatment.
This is because of a compensatory response of the liver to metabolize SAMe and prevent its accumulation.
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