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Coming Soon, Drug to Prevent Deadly Immune Response

by Kathy Jones on August 28, 2010 at 10:59 PM Drug News

A molecule, small enough to be used as a drug, that can shut down a dysfunctional immune response has been isolated by scientists.

Coming Soon, Drug to Prevent Deadly Immune Response

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This response causes deadly hemorrhagic shock, results in delayed death of heart attack patients, promotes rejection of transplanted organs and destroys joints in patients with rheumatoid arthritis, according to a study.

The molecule, a modified peptide, was extracted from the relatively huge protein shell of a common virus that is a frequent cause of childhood diarrhea, according to the research conducted by a team at Eastern Virginia Medical School and Children's Hospital of The King's Daughters.

The discovery marks a quantum leap toward clinical application by creating a powerful effect with a molecule small enough to be used in medications.

"This puts us in a position to move rapidly from in-vitro testing to in-vivo testing," says Neel Krishna, PhD, an assistant professor of microbiology and molecular cell biology at EVMS and a pediatric virologist at CHKD.

Five years back, the researchers inserted a shell of a virus that causes childhood diarrhea into a Petri dish primed to measure the response of a primordial component of the human immune response known as the complement system.

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Coming Soon, Drug to Prevent Deadly Immune Response

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