login
Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Combine Existing Prostate Cancer Drugs With New Ones at Lower Doses for Better Results, Say Australian Doctors
Professor Wayne Tilley and Dr Lisa Butler of the University's Dame Roma Mitchell Cancer Research Laboratories Butler have successfully killed prostate cancer cells in laboratory studies using low doses of a combination therapy of drugs including bicalutamide (an anti-androgen that opposes the action of androgen on the tumour), and the inhibitors 17AAG and vorinostat.
These new drugs block key cancer survival pathways, but are not particularly effective in killing prostate cancer cells if given alone.
"We can now confirm that a very low level of bicalutamide is capable of inhibiting cancer cell proliferation by more than 10-fold when combined with either vorinostat or 17AAG, making our current treatments much more effective and causing fewer side effects," says Dr Lisa Butler.
All the drugs needed for combination therapy are already approved for use in clinical trials, so the new therapy can be readily tested in patients with advanced prostate cancer.
Growth of prostate cancer is initially dependent on hormones called androgens, which traditionally have been suppressed to stop tumour growth. However, despite an initial response, resistance to hormone deprivation often occurs and the tumour starts to grow again, Professor Tilley says.
"Men undergoing hormone deprivation therapy can also experience significant side effects, including reduced libido, impotence, hot flushes, tiredness and sweating, gradual decrease in body hair, reduced bone and muscle strength and cognitive changes," he adds.
|
|
|
More News on: Drug Toxicity, Prostate Cancer, Cancer and Homeopathy, Check your prostate gland, Prostatitis Symptom Score Calculator, Trans-Urethral Resection of the Prostate, Signature Drug Toxicity, Prostate Cancer Facts, Cancer Facts, Cancer
 Comment & Contribute
|
Medwonders Health Network
- Health News Index
|
|
 | Quiz on Cancer Looking for information on cancer? Go through medindia's Cancer quiz. 
|
- News Quick Links
 |
Cancer
Complete Medindia Resources
|
| News Categories: |
| » | Olympic Athlete's Body Via the 80-10-10 Raw Vegan Diet |
| » | Importance of Canned Foods To Help Tackle IOM Weight Of The Nation Recommendations, Highlights Study |
| » | US Rules Pomegranate Juice Claims Deceptive |
| » | Reducing Entrée Size Could Increase Fruit and Vegetable Intake in Children |
| » | Dieters Should Eat 300 Calories Less to Avoid Regaining Lost Weight After Dieting |
| More Diet News | |
|
