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Clinical Trial Offers Hope For Nut Allergy Cure

by Sreeraman on February 20, 2009 at 1:00 PM Child Health News

A team of British scientists have come one step closer to curing nut allergies after a small-scale clinical trial in which they successfully built up children's tolerance to peanuts, they said Friday.

Clinical Trial Offers Hope For Nut Allergy Cure

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Researchers at Addenbroke's Hospital in Cambridge, eastern England, gave small daily doses of peanut flour to four children who were severely allergic to peanuts, building up the amount over time.

By the end of the trial, each child could ingest at least 10 peanuts without having any reaction, which the scientists noted was more than enough to protect against any accidental ingestion through nut-contaminated foods.

In the study, published in the journal Allergy, four children were initially given five milligrams of peanut flour mixed into yoghurt.

Over the next six months, the dose was increased every fortnight until they could tolerate at least 800 mg -- the equivalent of five whole peanuts.

The trial is ongoing and 20 children aged seven to 17 are now involved, with some able to ingest 12 peanuts a day.

However, they must maintain their tolerance by ingesting five peanuts a day, said Andrew Clark, a consultant in paediatric allergy who led the research.

"At the moment we know that if they continue to eat five peanuts a day, their tolerance is maintained. If they were to stop, then there is some evidence that tolerance would be lost and they may have a reaction," he said.

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