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Circadian Rhythm Regulated By Hydrogen Peroxide

Wednesday, November 11, 2009 at 8:59:05 AM

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A chemical that scientists from University of Southern California have identified appears to play a vital role in regulating our circadian rhythms.

The chemical is hydrogen peroxide (H2O2), the active ingredient in colour safe bleach. Produced in all animal cells, hydrogen peroxide may act as a signal for the active and resting phases of living things.

The study showed that hydrogen peroxide given to fruit flies has dramatic effects on their daily rhythms and activity levels.

"H2O2 might be functioning as a systemic signal by which rhythms are regulated within cells and between cells," said lead author John Tower, associate professor in molecular and computational biology at the USC College of Letters, Arts and Sciences.

Most people are familiar with the concept of a circadian rhythm that governs sleeping and waking. But that is not the only circadian rhythm in the body.

Many organs and tissues within the body have their own independent circadian rhythms, and they also interact to coordinate their rhythms.

Mitochondria produce hydrogen peroxide as a by-product of oxygen combustion, making the chemical a candidate signal molecule.

"This is a logical way to connect rhythms to metabolism," Tower said. "We know a lot about how circadian rhythms are regulated within certain cells. However, we have very little information on what signals coordinate circadian rhythms and how these rhythms are linked between metabolism and behaviour."

For the rhythms of even two cells to agree, some sort of signal has to pass between them.
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