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Chronic Constipation Finds New Treatment
Two studies, published in the New England Journal of Medicine, have ushered in good news to those suffering from chronic constipation!
The placebo-controlled study analyzes a new experimental medication, that is believed to relieve the pain and bloating associated with persistent constipation.
The new drug, linoclotide relieved chronic constipation in up to 21%, compared to the 6% who gained relief from a placebo.
Chronic constipation is common among women, the elderly and in those suffering from irritable bowel syndrome. According to statistics, one in five Americans suffer from this condition and had fewer than three bowel movements a week for long periods, the least being three months.
About Linoclotide
Researcher Anthony J. Lembo, MD, a gastroenterologist at Beth Israel Deaconess Medical Center in Boston, remarks that linoclotide works in an unique fashion in that it stimulates cells in the bowel lining to produce secretions that help to draw more fluid into the gut where the fluid helps to soften stool and hastens its passage.
However Lembo cautions that "It won't help everybody, of course. Not all patients have their symptoms relieved.There are a lot of different causes for constipation”
In USA and Canada, researchers recruited more than 1,200 adults (approximately 600 in each study) with histories of chronic constipation. These patients experienced symptoms such as straining, lumpy stools, and a feeling of incomplete stool passage.
In both trials, people were randomly assigned to any one of three groups:
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