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Childhood Developmental Disorders Risk Increased by Anesthesia Exposure
Recent animal studies have shown that commonly used anesthetic agents may have serious neurotoxic effects on the developing brain.
To assess whether the experimental animal data can be applied to humans, Lena S. Sun, M.D., professor of anesthesiology and paediatrics and colleagues at Columbia University College of Physicians and Surgeons, the Mailman School of Public Health and the Columbia University School of Nursing, performed an analysis of a group of children born into the New York State Medicaid Program between 1999 and 2000.
Over a 4 year period, 625 children under the age of three were exposed to general anesthesia as part of uncomplicated hernia repair.
When compared to a random sample of 5,000 children with no history of anesthesia exposure, the children exposed to anesthetic agents were twice as likely to be (subsequently) diagnosed with a developmental or behaviour disorder.
"Given that the study subjects were taken from a Medicaid population, one limitation of the data is the demographic factors of this group that may vary from the general population. The excess risk of developmental and behavioral disorders in the children exposed to anesthesia cannot be completely explained by demographic factors or confounding health factors including premature birth or low birth weight," the authors said.
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More News on: Dental Anesthesia, Spinal and Epidural Anesthesia, Local Anaesthesia, General Anesthesia, Anaesthesia - History, Anaesthesia - History and Origins, Post operative Complications
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