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Childhood Abuse Victims Carry Chemical Changes to DNA into Adulthood
Study leader Michael Meaney, a neurobiologist at the university, says that the research team observed that suicide victims with childhood abuse history were more likely to carry such chemical changes in their DNA as could affect their ability to respond to stress as adults.
He revealed that people without childhood abuse history did not show the same pattern of DNA modification, and had normal expression of NR3C1, a gene linked to stress responses.
However, Joan Kaufman, a psychologist at Yale School of Medicine in New Haven, Connecticut, who was not involved in the new study, said that the findings should not be taken to suggest that the effect of childhood abuse is indelible.
"The long-term effects of early abuse are not inevitable, and the more you understand about the mechanisms of risk, the more you can devise treatments," Nature magazine quoted her as saying.
The current research builds on animal studies that showed that rat pups that are stressed because they were raised by negligent mothers have extra methyl groups in their DNA in a region of the genome that controls expression of Nr3c1, the equivalent gene in rats.
The researchers point out that such 'methylation' can reduce gene expression.
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