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Cerebrovascular Diseases Strike People With Fluctuating BP: Study
The study appears in the May issue of Archives of Neurology, one of the JAMA/Archives journals.
Cerebrovascular disease, which includes stroke and other disorders affecting blood vessels in the brain, is associated with cognitive decline and disability in older adults, according to background information in the article.
Elevated blood pressure can cause cerebrovascular disease and has also been shown to be associated with poorer cognitive function and the risk for Alzheimer's disease. Studies that examine associations between blood pressure and cerebrovascular disease generally consider blood pressure measurements at only one time point.
Adam M. Brickman, Ph.D., of Columbia University's Taub Institute, New York, and colleagues studied 686 older adults without dementia who had blood pressure measurements taken during three study visits at 24-month intervals and underwent structural magnetic resonance imaging (MRI) to detect cerebrovascular disease. The researchers divided the participants into four groups depending on whether their blood pressure was high or low and whether they had high or low fluctuations in blood pressure between visits.
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