login
Become a member
Quick Registration
Full Registration Benefits -
Free Homepages for Doctors
Free Homepages for Hospitals
Free Homepages for Medical Conference
Free Homepages for NGO's
Personal Health Record Creation
Access to all Medical Slides
Access to all Jobs & Products Sale
Causes of Neural Disconnection in Schizophrenia
This structural abnormality is particularly relevant in schizophrenia, where pyramidal neurons located in layer 3, the principal cell type receiving communication from other brain regions, have fewer dendritic spines.
Studying this phenomenon further, researchers at the University of Pittsburgh now provide new insights into the dendritic spine deficits in schizophrenia. Drs. Masayuki Ide and David Lewis studied postmortem brain tissue of individuals diagnosed with schizophrenia and compared it to tissue from healthy individuals.
They found that the expression levels of two gene products, CDC42EP3 and septin 7, were higher and lower, respectively, in tissue from those with schizophrenia. CDC42EP3 and septin 7 play important roles in regulating spine plasticity. Since CDC42EP3 is preferentially expressed in layer 3, the findings suggest that the altered expression of these transcripts may contribute to the layer-specific deficits in dendritic spines associated with schizophrenia.
"We still have a long way to go to fully understand the neurobiology of schizophrenia. An important step in this process will be to begin to learn what we can about neural structure and chemistry from postmortem brain tissue from individuals diagnosed with schizophrenia," commented Dr. John Krystal, Editor of Biological Psychiatry. "These studies may help, ultimately, to develop new treatments that attempt to prevent or reverse these disturbances in brain structure associated with schizophrenia."
Dr. Lewis agreed, remarking that "These findings provide a potential basis for novel treatments for schizophrenia, and for preemptive interventions for individuals who are at high risk for the illness."
Source-Eurekalert
|
|
More News on: Schizophrenia
 Comment & Contribute
|
|
kankesh8(Guest)
07/10/2010
my son having schiphonia from last 8 years he is not doing any thing he is aggrassive please advice
Reply |
Forward
|
Medwonders Health Network
- Health News Index
- News Quick Links
 | News Central | | Health Watch | |
| Latest Health News | | Health In Focus | |
| News Category (500+) | | Breaking Health News | |
| Popular News | | Celebrating Life | |
| Health News and Press Release | | Medindia - Exclusive | |
| News Photo Gallery | | India Special | |
| News Video Gallery | | Lifestyle and Wellness | |
| News From Other Resources | |||
 |
Schizophrenia
Complete Medindia Resources
|
| News Categories: |
| » | Scientists Develop Compound That Triggers Cancer Cell Death |
| » | Iraqi National Hopes to Find Affordable Treatment for His Cancer in India |
| » | New Technique can Help Doctors Detect Pancreatic Cancer |
| » | Colorectal Cancer Risk Factors Probed |
| » | Breast MRI 'Better Than Clinical Approach for Predicting Chemotherapy's Efficiency' |
| More Cancer News | |
|
Research Related News |
||||||||
| » | Lack of Vitamin D in Diet Raises Stroke Risk in Japanese-Americans | » | Why Bovine TB Continues to Spread Demystified in New Research | |||||
| » | Seaweed Pill May Help Treat Arthritis | » | P. Aeruginosa Infection Leads to Worse Outcomes and Increased Hospitalizations in COPD Patients | |||||
| » | Hormone Boosts Production of Molecules Which Fight Skin Infection | » | Protein Discovery Could Lead To New Vaccine for Meningitis | |||||
| » | Qui Vive: Intense Nuclear Radiation Threat, Scientists | » | 'Miracle' Diet of Reverse Engineering Epilepsy | |||||
| Read More >> | ||||||||
