It is now possible to find out the reason behind the failure of kidney transplants, courtesy a simple and recently introduced urine test.
The novel test may help lead to better diagnosis and treatment of patients with polyomavirus nephropathy, which affects about 9 percent of kidney transplant patients.
About Transplantation
Since the early times, the novel idea of transplanting tissues and other body parts from one organism to the other has captured the imagination of successive generations.
Since the early times, the novel idea of transplanting tissues and other body parts from one organism to the other has captured the imagination of successive generations.
While polyomaviruses are normally occurring viruses that harmlessly infect many adults, they can pose serious health problems for individuals who become immunocompromised. Such is the case for many kidney transplant recipients who must take immunosuppressive medications to safeguard against organ rejection.
Some of these patients develop a damaging condition called polyomavirus nephropathy that can lead to chronic kidney failure and the need to re-initiate dialysis or undergo another transplant.
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ow Volker Nickeleit, MD, of the University of North Carolina in Chapel Hill, North Carolina and his colleagues have discovered a new and noninvasive way to test for the condition.
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Through their investigation, the researchers found Haufen in urine samples from all 21 patients with early or late stages of polyomavirus nephropathy, but not in any of the 139 individuals without the condition.
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"An early and accurate diagnosis of polyomavirus nephropathy will result in a better understanding of the disease and ultimately improve treatment," he said.
"Our diagnostic test is unique and could have a tremendous clinical impact," he added.
Source-ANI
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