Medindia

X

Cathepsin B Boosts Apoptosis in Fulminant Hepatic Failure

by VR Sreeraman on  March 23, 2009 at 11:17 AM Research News   - G J E 4
 Cathepsin B Boosts Apoptosis in Fulminant Hepatic Failure
The traditional view is that hepatocyte necrosis is the main feature of fulminant hepatic failure, but increasing evidence implicates a dominant role for hepatocyte apoptosis in this pathogenesis. It is not known if cathepsin B-mediated hepatocyte apoptosis is involved in the pathogenesis of fulminant hepatic failure.
Advertisement

To ascertain its pathogenic role in hepatic failure, the research examined the protective effect of a cathepsin B inhibitor (CA-074Me) on fulminant hepatic failure in mice.

Advertisement
A research article to be published on March 14, 2009 in the World Journal of Gastroenterology addresses this question. The research team led by Prof. Yang in the Department of Infectious Diseases of the Second Clinical Hospital of Harbin Medical University investigated cathepsin B expression changes in the liver of fulminant hepatic failure.

The article further indicated that LPS/D-Gal N-mediated cathepsin B expression initiates hepatocyte apoptosis in fulminant hepatic failure.

Cathepsin B, a lysosomal cysteine protease, is a candidate for an apoptotic mediator originating from acidic vesicles. CA-074me is a selective inhibitor of cathepsin B , and it is highly cell-permeant and can decrease the expression or activity of cathepsin B. The traditional view is that hepatocyte necrosis is the main feature of fulminant hepatic failure, but increasing evidence implicates a dominant role for hepatocyte apoptosis in this pathogenesis.

Inhibition of cathepsin B attenuates apoptosis and liver injury, supporting a link between cathepsin B and fulminant hepatic failure, and thus may provide new targets for further understanding of the pathogenesis of fulminant hepatic failure and new therapeutic targets.

Source: Eurekalert
SRM
Advertisement

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions

You May Also Like

Advertisement
View All