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Cancer Genomes Feature Distinguishing 'Driver' and 'Passenger' Mutations
The study also found that at least one in nine genes could be removed without harming human cells.
Many cancer genomes are full of mutations. The vast majority of these are likely to be passengers - mutations that don't contribute to the development of cancer but have occurred during the growth of the cancer - while a small minority are the critical drivers.
Prof Mike Stratton, senior author on the study from the Wellcome Trust Sanger Institute, said: "It is essential that we can distinguish the drivers from the passengers because knowing the driver mutations and hence the critical genes they are in leads to understanding of the cellular processes that have been subverted in cancers and hence to new drugs.
"Our study provides one example of how researchers can sift through the large numbers of a particular type of mutation present in cancer genomes in order to distinguish drivers from passengers."
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