Guidelines for the research and reproductive use of stem cell-derived eggs and sperm are needed, according to more than 40 scientists, bioethicists, lawyers and science journal editors. They are calling on their colleagues, policy makers and the public to develop such guidance although actual use may be years away.

"Science has always moved faster than social debate or society's ability to grapple with these issues," says Debra Mathews, Ph.D., lead author of a paper published in the July issue of Cell Stem Cell and assistant director of science programs at the Johns Hopkins Berman Institute of Bioethics. The paper calls for all parties to begin engaging in open discussion and debates, and describes the need for informed social policy well in advance of the eventual use of eggs and sperm derived from pluripotent stem cells.

Mathews said stem cell researchers need to be better prepared to address public questions about uses of so-called pluripotent stem cell-derived gametes -- regardless of how realistic or soon those uses may be. Such uses would potentially include reproductive uses such as the creation of sperm and eggs for in vitro fertilization, embryo selection based on genetic profile, and the creation of embryos from the tissues of fetuses, children and the deceased.

The issues are too complex, and the stakes are too high, the authors suggest, for the public to be caught unaware by some new capability for using stem cell-derived gametes, and the research already is moving rapidly toward generation of sperm and eggs capable of making human embryos and potentially children.