Calcium, Vitamin D Supplements Do Not Reduce Breast Cancer Risk

by VR Sreeraman on  November 13, 2008 at 4:21 PM Cancer News   - G J E 4
Calcium, Vitamin D Supplements Do Not Reduce Breast Cancer Risk
A new study has revealed that taking calcium and vitamin D supplements does not reduce breast cancer incidence in postmenopausal women.

Some studies have suggested that vitamin D supplements may reduce breast cancer risk, but results have been inconsistent.

In the new study, Rowan Chlebowski, M.D., Ph.D., of the Los Angeles Biomedical Research Institute at Harbor-University of California Los Angeles Medical Center and colleagues evaluated breast cancer incidence as a secondary endpoint in the Women's Health Initiative study in 36,282 postmenopausal women who were randomly assigned to take 1,000 mg of calcium plus 400 IU of vitamin D daily or to daily placebo.

Baseline 25-hydroxyvitamin D levels was determined in all 1,067 breast cancer cases and 1,067-matched control subjects.

The researchers found that the incidence of invasive breast cancer was similar in the supplement and placebo groups, with 528 and 546 cases, respectively.

Also, 25-hydroxyvitamin D levels were only modestly associated with dietary and supplement vitamin D intake and were not associated with breast cancer risk in a nested case-control analysis.

These findings call into question recommendations for evaluation of higher vitamin D dosage in future studies, according to the authors.

In addition, as 25-hydroxyvitamin D levels were strongly associated with leanness and high physical activity, which both influence breast cancer risk, prior observational studies relating vitamin D levels to breast cancer risk may have been influenced by these factors.

"The main findings do not support a causal relationship between calcium and vitamin D supplement use and reduced breast cancer incidence," the authors said.

The study is published online November 11 in the Journal of the National Cancer Institute.

Source: ANI

Post your Comments

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
User Avatar
* Your comment can be maximum of 2500 characters
Notify me when reply is posted I agree to the terms and conditions
This study was based on 400 IU/day vitamin D. It takes over 1000 IU/day to have an easily seen beneficial effect. Search "vitamin d breast cancer" to find other papers reporting a benefit of vitamin D in reducing the risk of breast cancer.
William B. Grant Thursday, November 13, 2008

You May Also Like