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Calcium-Sensing Receptor Makes Lung Cancer Deadlier
The protein previously thought not to exist in adult human lungs is present in both normal and cancerous lung tissues. It sits on the surface of lung cancer cells that make up tumors known as squamous-cell carcinomas, according to new research.
As these tumors grow, the receptor releases a hormone that sets off a biological cycle that leads to the erosion of bone throughout the body. When the bone breaks down, calcium is released. The excess calcium that cant be filtered by kidneys cycles back to the receptors, which release more of the damaging hormone. That same hormone promotes the growth and spread of cancer.
Knowing the receptors role in squamous-cell lung cancers will help guide future research on new treatment options for both the cancer and hypercalcemia, said Gwendolen Lorch, assistant professor of veterinary clinical sciences at Ohio State University and lead author of the study.
The calcium-sensing receptor clearly has a huge role in hypercalcemia. Though its too soon to say it could be a target for treatment, we wont ever be able to find the right target if we dont know how hypercalcemia develops in the first place, Lorch said.
The researchers also found that lung cancer patients who have a specific type of inherited genetic mutation are at risk of developing hypercalcemia earlier than others. This finding is likely to have clinical implications in the future, as sequencing of the human genome becomes more affordable and available as part of standard medical care, Lorch said.
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