Brit scientists have discovered a mechanism in the body that causes high blood pressure-a feat that could lead to new treatments for the condition.
Researchers have found for the first time a key step in how the body controls blood pressure and so how the process sometimes goes wrong.
And now they can target the mechanism to stop it from malfunctioning and thus prevent the condition, known as hypertension, which is the leading cause of heart disease and stroke.
The researchers at Cambridge University and Nottingham University discovered the mechanism while studying pre-eclampsia, a potentially deadly form of high blood pressure which occurs in women during pregnancy.
Blood pressure is controlled by hormones called angiotensins which in too high a dose forces blood vessels to contrict, increasing blood pressure.
The scientists, who have spent 20 years researching the hormones, have discovered the very first stage in their development.
They now believe they could develop a way of inhibiting the "switch" that allows the hormones to overproduce and prevent the onset of high blood pressure.