Breast Cancer Risk is Not the Same Among Different Progestins Employed in HRT

by Savitha.C.Muppala on  August 13, 2010 at 11:57 PM Cancer News
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"Although previous studies using an animal model for breast cancer found that MPA functions as a tumor promoter, this study show that N-EL and N-One, when administrated using the same protocol as used for MPA, strongly inhibited tumor development," said Hyder.

"Thus progestins seem to have tumor-stage specific effects, which determine whether these will function as tumor promoters or tumor suppressors. Progestins, such as N-EL and N-ONE, may have potential as preventive agents in women with no history of breast disease or family history of breast cancer. These progestins may also have a preventive role in post-menopausal women who are at an increased risk for developing breast cancer due to ingestion of combined estrogen/progestin (MPA) hormone replacement therapy and may have early stage disease," he added.

The study has been published in the September issue of Cancer Prevention Research from the American Association for Cancer Research.

Source-ANI
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