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Breast Cancer Risk is Not the Same Among Different Progestins Employed in HRT

by Savitha.C.Muppala on August 13, 2010 at 11:57 PM Cancer News

Researchers found different outcomes on the advancement of breast cancer on comparing four types of progestins used in hormone replacement therapies.

Breast Cancer Risk is Not the Same Among Different Progestins Employed in HRT

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Progestins are used in hormone replacement therapies to counteract the negative effects of estrogen on the uterus and reduce the risk of uterine cancer. However, evidence in recent studies and clinical trials has demonstrated that progestins increase the risk of breast cancer.

But it is now that theUniversity of Missouri researchers have come to the above conclusion.

"Synthetic progestins have different biological effects, due to differences in their structure, stability and how they interact in the body. Clinical use of progestins requires caution. These powerful steroids should only be prescribed when a person has no latent, or dormant, cancer and does not have a family history of cancer. However, it is difficult to diagnose latent tumor cells in women since there are no symptoms," said Salman Hyder, the Zalk Endowed Professor in Tumor Angiogenesis and professor of biomedical sciences in the College of Veterinary Medicine and the Dalton Cardiovascular Research Center.

In the study, researchers compared the effects of four clinically relevant progestins on breast cancer tumors in an animal model.

The progestins used in the study were the synthetic progestin medroxporgresterone acetate (MPA), norgesterel (N-EL), norethindrone (N-ONE) and megestrol acetate (MGA). In the United States, most women on hormone replacement therapy are treated with MPA, the progestin in Prempro, said Hyder.

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Breast Cancer Risk is Not the Same Among Different Progestins Employed in HRT

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