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Breakthrough in Human Metabolic Function and Physiology Developed With Snake Proteins
They said that their findings may enable researchers to understand how other animals including humans accomplish aerobic respiration, and may also reveal details about protein function and evolution important for human health.
Earlier snakes were recommended as an ideal model system to study evolution, and results of this new study also support that idea, showing that their use as a model system can even extend to the molecular level.
In the last decade, it was shown that snakes have remarkable abilities to regulate heart and digestive system development and they endure among the most extreme shifts in aerobic metabolism known in vertebrates. This clearly makes snakes an excellent model for studying organ development, as well as physiological and metabolic regulation. But, this uniqueness of snakes has not been reasoned previously at the molecular level.
In this study, David Pollock, PhD, associate professor of biochemistry and molecular genetics at the UC Denver School of Medicine, and his colleagues provide evidence that the major evolutionary changes that have occurred in snakes, such as adaptations for their extreme physiology and metabolic demands, loss of limbs and the evolution of deadly venoms, was accompanied by massive functional redesign of core metabolic proteins.
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