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Brain Tumors Need Treatment With Multiple 'targeted' Drugs: Study
September 17, 2007 at 7:41 PM
Cancer News
The switches are formed by molecules called receptor tyrosine kinases (RTKs) that often are mutated and hyperactive in cancer cells. Since a number of kinase-blocking drugs are already available -- Gleevec and Tarceva are two of the best-known -- the researchers said clinical trials of combinations of the compounds should be planned quickly.
"This is a transformative finding that will motivate clinicians and our pharmaceutical colleagues to design clinical trials with regimens using several inhibitors," said DePinho. He noted that in the laboratory study using cancer cell lines and fresh specimens of brain tumors, three or more kinase inhibitors were needed to quell the abnormal cell-growth signals.
The study focused on glioblastoma multiforme (GBM), an aggressive brain tumor that is nearly always fatal. The scientists also found similar patterns of multiply activated RTKs in other common cancers of the pancreas and lung.
Jayne Stommel, PhD, lead author of the report and a post-doctoral fellow in the DePinho lab, undertook a survey of molecular RTK "signaling pathways" in GBM cells to find the sources of abnormal growth.
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More News on: Parkinsons Disease, Parkinsons Disease Surgical Treatment, Brain Tumors, Brain, Tumor Markers For Cancer Diagnosis and Prognosis, Brain Facts, Ataxia
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