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Brain Cells Made into Heart Cells Successfully

by Tanya Thomas on  July 10, 2011 at 8:06 PM Research News   - G J E 4
Researchers have long anticipated that heart cells-the most sought-after cells in regenerative medicine-may help to repair injured hearts by replacing lost tissue and save millions of lives.
 Brain Cells Made into Heart Cells Successfully
Brain Cells Made into Heart Cells Successfully
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While researchers have spent more than a decade trying to reprogram cell types in general, changing them into heart cells has so far been a stubborn challenge.

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Now, a team at the Perelman School of Medicine at the University of Pennsylvania is the first to demonstrate the direct conversion of a non-heart cell type into a heart cell by RNA transfer.

Working on the idea that the signature of a cell is defined by molecules called messenger RNAs (mRNAs), which contain the chemical blueprint for how to make a protein, the investigators changed two different cell types, an astrocyte (a star-shaped brain cell) and a fibroblast (a skin cell), into a heart cell, using mRNAs.

"What's new about this approach for heart-cell generation is that we directly converted one cell type to another using RNA, without an intermediate step," says James Eberwine, a pharmacology professor at Penn.

The team says that reprogramming a patient's cells to be heart cells would permit personalized screening for efficacy of drug treatments; screening of new drugs; and potentially as a cellular therapeutic, the researchers said.

The study has been published in the Proceedings of the National Academy of Sciences.

Source: ANI
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