About Us Portfolio Press Careers Sitemap Advertise Contact Us Make this your Homepage

Custom Search

Register

Sign In

Sign In Using Facebook

Home » Drug News

Bosutinib Fairly Safe For Chronic Myelogenous Leukemia

December 13, 2007 at 6:50 PM Drug News

Related Links

A new drug for chronic myelogenous leukemia works for patients who have developed resistance to frontline therapy and causes fewer side effects than other medications in its class, a research team led by scientists at the University of Texas M. D. Anderson Cancer Center reports at the 49th annual meeting of the American Society of Hematology.

"Bosutinib has shown good efficacy and very little toxicity compared to other tyrosine kinase inhibitors at this stage of the clinical trial," says lead researcher Jorge Cortes, M.D., professor in M. D. Anderson's Department of Leukemia.

Bosutinib, developed by Wyeth Pharmaceuticals, is being tested in patients in the early or chronic phase of CML whose disease has become resistant to imatinib or who have become intolerant of imatinib's side effects.

So far, 98 patients have enrolled in the relatively new clinical trial, with median duration of treatment at 5.1 months.

Among 23 evaluable patients who had become resistant to imatinib, 17 (74 percent) achieved a complete hematological response - normal blood counts. Of 36 evaluable for cytogenetic response - reduction of the abnormal chromosome that causes the disease - 15 had a major response and 12 of those had a complete response, or absence, of the chromosome.

"These responses are comparable to other drugs at a similar stage of follow-up," Cortes says.

Interestingly, a small number of patients who had also become resistant to second-line treatments nilotinib and dasatinib derived some benefit from taking the new drug. Out of eight such patients, three achieved complete hematologic response and two achieved major cytogenetic

Page 1

Page 1 | 2

Next

Cellular Receptors Used To Track Prostate Cancer

Statins Might Pose Risks For Stroke Victims

More News on: Leukemia, Multiple Myeloma, Chronic Myeloid Leukemia, Acute Myeloid Leukemia

Comment & Contribute

Be the first to comment!
Comments should be on the topic and should not be abusive. Comments are normally moderated and are reviewed after they are posted.
* Your comment can be maximum of 2500 characters
	Notify me when reply is posted I agree to the terms and conditions
Your comments are automatically posted once they are submitted. All comments are however constantly reviewed for spam and irrelevant material (such as product or personal advertisements, email addresses, telephone numbers and website address). Such insertions do not conform to our policy and 'Terms of Use' and are either deleted or edited and republished. Please keep your comments brief and relevant.This section may also have questions seeking help. If you have the information you are welcome to respond, but please ensure that the information so provided is genuine and not misleading.

Medwonders Health Network

Support Groups Members Discussions

Total Members - 54992
Support Groups - 445

Health News Index

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Latest News Most Popular Most Commented

Organ Damage in Inflammatory Genetic Disorder Arrested by Rheumatoid Arthritis Drug

Kids' Gadget Perplex 1 In 6 Parents

Immune System Regulation Directly Affected If Raised on a Farm

Shortly, Memory- Impaired Patients to Get Smartphone 'Prescription'

Sporting Activity in Excess Could Mar Long-Term Success of Hip Resurfacing

News Archive
Date :
Category :
Keyword :

News Quick Links

	News Central			Health Watch
	Latest Health News			Health In Focus
	News Category (500+)			Breaking Health News
	Popular News			Celebrating Life
	Health News and Press Release			Medindia - Exclusive
	News Photo Gallery			India Special
	News Video Gallery			Lifestyle and Wellness
	News From Other Resources

Leukemia

Complete Medindia Resources

News Categories:


»	Antidepressants and the Risk of Sudden Unexpected Death in Epilepsy

»	Research Says Financial Burden of Prescription Drugs is Dropping

»	New Guidelines to Avoid Heparin Contamination

»	Weight Loss Drug Has Killed At Least 1,300 in France

»	FDA Approves Sanofi�s Treatment for Head Lice
More Drug News

Drug Related News
»	Antidepressants and the Risk of Sudden Unexpected Death in Epilepsy	»	Research Says Financial Burden of Prescription Drugs is Dropping
»	New Guidelines to Avoid Heparin Contamination	»	Weight Loss Drug Has Killed At Least 1,300 in France
»	FDA Approves Sanofi�s Treatment for Head Lice	»	New Scoring Method may Help Decide Who Will Benefit From Stroke Drug
»	New Guidelines Recommend Metformin to Treat Type 2 Diabetes	»	Novel Prostate Cancer Drug Target Identified

Read More >>

Bosutinib Fairly Safe For Chronic Myelogenous Leukemia

Medwonders Health Network

Drug Related News

Consumers

Medical Professionals

Medical Students

Directories