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Bone Marrow Stem Cells Can Help Treat Killer Skin Disease
Researchers led by University of Minnesota doctors John Wagner and Jakub Tolar used bone marrow stem cells to treat children with a rare genetic skin disorder called recessive dystrophic epidermolysis bullosa (RDEB).
The study was the first to show that bone marrow stem cells can be used to treat diseases affecting the skin and upper gastrointestinal tract, and alter the course of epidermolysis bullosa (EB), which causes skin to blister and scrape off with the slightest rub or bump -- and for which there is no cure.
EB can also affect the lining of the mouth and esophagus, as well as the skin, and makes activities that many children take for granted, such as eating, painful.
Seven children were enrolled in the trial which ran from 2007 to 2009. One child died before doctors could transplant healthy bone marrow stem cells, and another died six months after the transplant.
But the remaining five were all better, Tolar told AFP.
"Their skin is better, they are more active, they use fewer bandages, they have donor cells in their skin and we have been able to show that they produce the all-important collagen 7 in their skin," he said.
Collagen 7, a protein that keeps layers of skin "glued" to each other and to the body, is missing in EB sufferers.
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