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Boffins Identify Protein That Regulate Water Retention in Salt-Sensitive Hypertension
These findings by the LSU Health Sciences Centre New Orleans may lead to advances in treatment for diseases like high blood pressure, congestive heart failure, and cirrhosis of the liver.
Daniel Kapusta of the LSU Health Sciences Center and Richard Wainford of LSUHSC reported the role of these brain proteins, called Gaq and Gaz, in producing elevated secretion of the hormone, vasopressin, and water retention in salt-sensitive hypertension, a condition in which blood pressure becomes elevated when salt is consumed.
"Throughout the day, vasopressin, a peptide hormone produced by the hypothalamus, is released into the circulation from the pituitary gland and plays a vital role as the flood-gate keeper to prevent excessive loss of water from the kidneys.
"Under most conditions, the water-retaining action of vasopressin is vital for survival. However, it has remained essentially a black box as to why, in susceptible individuals, the regulatory mechanisms that control vasopressin secretion cannot turn off when the body already has elevated water content," said Kapusta.
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