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Boffins Identify Genes Linked to Aggressive Breast Cancer

by Tanya Thomas on August 18, 2010 at 10:58 AM Cancer News

For the first time, scientists have identified 12 genes that could be associated with aggressive breast tumours.

Researchers at the University of Gothenburg, Sweden, say their discovery could result in more reliable prognoses and better treatment strategies for patients.

Boffins Identify Genes Linked to Aggressive Breast Cancer

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The results are based on analyses of breast tumours from 97 female breast cancer patients. Half of these patients died within eight years of diagnosis, while the remainder survived for more than eight years.

Breast tumours consist of a heterogeneous mix of tumour cells which are markedly different in terms of their genes (DNA) and biological properties. The researchers used microarray techniques to study the overall picture of the tumours by measuring the amount of DNA and gene products (RNA) in each tumour.

This enabled them to investigate the relationship between genetic changes and clinical parameters such as tumour properties and response to treatment.

"We've managed to identify 12 genes whose expression is associated with an aggressive form of breast cancer. These 12 genes were much more prominent in patients who died within eight years than in those who survived," said Toshima Parris, a PhD student at the Department of Oncology

Three of these 12 gene products were represented in much higher levels in aggressive breast tumours than in less aggressive tumours, whereas the nine remaining genes were found in lower levels in aggressive tumours.

These findings suggest that the activity of these genes could have an effect on tumour progression by impacting cell growth, motility and development.

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Boffins Identify Genes Linked to Aggressive Breast Cancer

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