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Bisphosphonates Can Triple Bone Necrosis
January 16, 2008 at 7:00 PM
Drug News
Bisphosphonates is a class of drugs used by millions of women worldwide to help prevent bone fractures due to osteoporosis.
The research led by Dr. Mahyar Etminan of the Centre for Clinical Epidemiology and Evaluation at UBC and VCHRI, is the largest study of bone necrosis and bisphosphonatesand also the first of its kind to look at the link between bone necrosis and specific brands of bisphosphonates, such as Actonel, Didrocal and Fosamax.
This study is based on the health records of 88,000 Quebec residents from 1996 to 2003. The team undertook the research after academic papers began linking necrosis of the jaw with the use of bisphosphonates.
The researchers discovered that all three brands had similar outcomes.
Bone necrosis is a relatively rare disease diagnosed in approximately 1 in 20,000 people per year and causes permanent loss of blood supply to the bones. When bloody supply is poor, the bone tissue dies and causes the bone to collapse.
This disease mainly affects shoulders, knees and hips at the joints, causing severe pain and immobility.
The findings come in line with a recent U.S. Food and Drug Administration alert about bisphosphonates that indicated the possibility of severe and sometimes incapacitating bone, joint and/or muscle pain in patients taking the drugs.
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