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Bisphosphonate Treatments Beyond Four Years May Cause Bone Fracture
Bisphosphonates are designed to slow or stop the bone loss that occurs during the body's bone remodeling cycle, or the natural process that involves removal and replacement of bone tissue.
Two separate studies by researchers from Hospital for Special Surgery (HSS) and Columbia University Medical Center on bisphosphonates were presented at the 2010 Annual Meeting of the American Academy of Orthopaedic Surgeons (AAOS). The studies suggested that long-term suppression of bone remodeling by bisphosphonate treatments may alter the material properties of bone, potentially affecting the bone's mechanical integrity and potentially contributing to the risk of atypical fractures.
"Although bisphosphonates have demonstrated an improvement in bone quantity, little if anything is known about the effects of these drugs on bone quality," said Brian Gladnick, BS, representing a team of investigators at HSS in New York.
Researchers at Columbia evaluated the bone structure of 111 postmenopausal women with primary osteoporosis, 61 of whom had been taking bisphosphonates for a minimum of four years and 50 controls taking calcium and vitamin D supplements.
This study found that bisphosphonate use improved structural integrity early in the course of treatment, but those gains were diminished with long-term treatment.
"In the early treatment period, patients using bisphosphonates experienced improvements in all parameters, including decreased buckling ratio and increased cross-sectional area," said Melvin Rosenwasser, MD, orthopaedic surgeon for Columbia University Medical Center. "However, after four years of use, these trends reversed, revealing an association between prolonged therapy and declining cortical bone structural integrity."
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More News on: Fracture, Fracture of Knee Cap , Infantile Cortical Hyperostosis, Colle’s Fracture, Fracture Neck of Femur
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