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Birth Defects Not Caused by Some Antiviral Drugs
An analysis of data from Denmark found no associated increased risk of major birth defects for mothers who were exposed during the first trimester of pregnancy to the antiviral drugs acyclovir, valacyclovir, and famciclovir, often used to treat herpes simplex and herpes zoster infections.
The prevalence of herpes simplex is high, and more than 1 percent of susceptible women acquire herpes simplex during the first trimester of pregnancy, with antiviral treatment indicated for a significant number of women in pregnancy.
"Although the safety of acyclovir, valacyclovir, and famciclovir in general has been well established, data on the use of these antivirals in early pregnancy are limited," the authors said.
Bjorn Pasternak, and Anders Hviid, M.Sc., Dr.Med.Sci., of Statens Serum Institut, Copenhagen, Denmark, conducted a registry-based study to assess associations between acyclovir, valacyclovir, and famciclovir use in the first trimester of pregnancy and major birth defects.
The study included 837,795 live-born infants in Denmark from January 1996 to September 2008. Participants had no diagnoses of chromosomal aberrations, genetic syndromes, birth defect syndromes with known causes, or congenital viral infections.
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More News on: Achondroplasia, Drug Toxicity, Birth Defect - Genetic, Birth Defects - Introduction, Drug-Induced Birth Defects, Environmental Birth Defects, Birth defects - Infections, Multifactorial Birth Defects, Birth Defect - Structural Defects, Klinefelters Syndrome
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