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Biochip Production may Speed-up Deadly Disease Diagnosis
Reporting their work in a paper in the Journal of the American Chemical Society (JACS), the researchers have described ‘protein chips’ as objects that have proteins attached to them, and that allow important scientific data about the behaviour of proteins to be gathered.
The Manchester team of Dr Lu Shin Wong, Dr Jenny Thirlway and Prof Jason Micklefield say that functional protein arrays may help run tests on tens of thousands of different proteins simultaneously, observing how they interact with cells, other proteins, DNA, and drugs.
Being able to place and locate proteins on a ''chip'' may make it possible to generate large amounts of data with the minimum use of materials, especially rare proteins that are only available in very small amounts, say the researchers.
They insist that their approach offers a reliable new way of attaching active proteins to a chip.
The researchers say that they have engineered modified proteins with a special tag, which makes them attach to a surface in a highly specified way, and ensures that they remains functional.
According to them, the attachment take place in a single step in just a few hours, and does not require any prior chemical modification of the protein of interest or additional chemical steps.
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