It has long been known that overweight people have a higher risk of heart attacks, strokes and other problems that arise from clogged, hardened arteries.
And now, a new study in mice gives the first direct evidence of why the connection between heart disease and belly fat also known as visceral fat exists and a look at how it might be broken.
Researchers from University of Michigan Cardiovascular Centre have reported the direct evidence of a link between inflammation around the cells of visceral fat deposits, and the artery-hardening process of atherosclerosis.
The researchers also show that a medication often given to people with diabetes can be used to calm that inflammation, and protect against further artery damage.
The study was led by Daniel Eitzman, M.D., a cardiologist, laboratory scientist and associate professor in the Division of Cardiovascular Medicine at the U-M Medical School and the VA Ann Arbor Healthcare System.
The researchers were interested to see if there might be any link between the inflammation and atherosclerosis - the formal name for the process by which blood vessels become stiff, narrowed and lined with plaque formations that can trigger the development of blood clots.
This process, which occurs throughout the body, sets the stage for most heart attacks and strokes. Scientists and clinicians now realize that it is based on inflammation the abnormal reaction of the bodys immune system to its own tissue and in the damage that immune-system cells and molecules can inflict.