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BP Drug Limits Lung Disease

by Sheela Philomena on  December 20, 2011 at 2:12 PM Drug News   - G J E 4
Lostartan - a drug widely used to treat high blood pressure reduces cigarette smoke-induced lung disease in mice, shows study.
 BP Drug Limits Lung Disease
BP Drug Limits Lung Disease
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The discovery by Enid Neptune and colleagues, at Johns Hopkins University, Baltimore, provides hope for the development of therapies for chronic obstructive pulmonary disease (COPD).

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COPD is among the most common causes of death in the US. It is a smoking-related disease for which there are currently no disease-altering therapies.

Losartan blocks the protein angiotensin receptor type 1, and its effects on cigarette smoke-induced lung injury were a result of the fact that blocking angiotensin receptor type 1 leads to a decrease in levels of the soluble molecule TGF-beta.

The authors therefore suggested that other TGF-beta-targeted therapeutics might also be viable candidates for the treatment of COPD.

Source: ANI
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