The second clonotype, BV16/BJ2S5, persisted following recovery, consistent with the hypothesis that the other, BV8S2/BJ2S7 T cell clonotype, is the driver of disease and necessary for EAE/MS persistence. The identification of this T cell subset suggests that these cells may be critical targets valuable to the design of therapies for autoimmune diseases such as MS.
AUTHOR CONTACT:
Eli E. Sercarz
Torrey Pines Institute for Molecular Studies, San Diego, California, USA.
Phone: (858) 455-3824; Fax: (858) 455-3715; E-mail: esercarz@tpims.org
Source-Eurekalert
JAY/M