About Us Portfolio Press Careers Sitemap Advertise Contact Us Make this your Homepage

Custom Search

Register

Sign In

Sign In Using Facebook

Home » Genetics & Stem Cells News

Autoimmune Response in Multiple Sclerosis

July 13, 2007 at 4:50 PM Genetics & Stem Cells News

In multiple sclerosis (MS), the myelin that surrounds the axons of nerve cells is attacked by the body’s own T cells, resulting in slowed and disrupted nerve impulses and, ultimately, axon loss.

Related Links

Myelin basic protein (MBP) is a major component of the myelin sheath and when used as an antigen will induce experimental autoimmune encephalitis (EAE) in mice, which is used as an animal model of human MS.

Interestingly, myelin-specific T cells are found in both healthy individuals as well as patients with MS, thus researchers have been working to determine what specific characteristic of these destructive T cells is dominant in driving the development of EAE/MS.

In a study appearing online on July 12 in advance of publication in the August print issue of the Journal of Clinical Investigation, Eli Sercarz and colleagues from the Torrey Pines Institute for Molecular Studies immunized mice with an epitope of MBP known as Ac1–9, which resulted in a single episode of EAE in these animals, followed by recovery and resistance to any reinduction of disease.

The authors then went on to characterize the Ac1–9–specific T cells present during the induction, onset, and recovery from disease. They identified two distinct subsets of T cells, or clonotypes, soon after immunization and prior to disease onset: BV8S2/BJ2S7 and BV16/BJ2S5.

The BV8S2/BJ2S7 clonotype was found in far greater excess, disappeared with disease recovery, and was found to transfer disease to other healthy mice.

Page 1

Page 1 | 2

Next

Food Fortification With Folic Acid Does The Trick

Suven Seeks Permission for Trials of New Drug

More News on: Chemotherapy Drugs, Multiple Sclerosis, Myasthenia Gravis, Vitiligo, Autoimmune Disorders, Microscopic Polyangiitis, Wegener’s Granulomatosis, Chemotherapy

Comment & Contribute

Be the first to comment!
Comments should be on the topic and should not be abusive. Comments are normally moderated and are reviewed after they are posted.
* Your comment can be maximum of 2500 characters
	Notify me when reply is posted I agree to the terms and conditions
Your comments are automatically posted once they are submitted. All comments are however constantly reviewed for spam and irrelevant material (such as product or personal advertisements, email addresses, telephone numbers and website address). Such insertions do not conform to our policy and 'Terms of Use' and are either deleted or edited and republished. Please keep your comments brief and relevant.This section may also have questions seeking help. If you have the information you are welcome to respond, but please ensure that the information so provided is genuine and not misleading.

Medwonders Health Network

Support Groups Members Discussions

Total Members - 54891
Support Groups - 445

Health News Index

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Latest News Most Popular Most Commented

Terminally Ill Cancer Patients Often Delay Discussing End-of-Life Care With Physicians

Research Says Financial Burden of Prescription Drugs is Dropping

Risk of Cardiac Events in Youth Not Increased by Stimulant Treatment for ADHD

Plastic Addicted Teen Has Consumed More Than 60,000 Goods

Cochlear Implants Safe For Organ Transplant Patients

News Archive
Date :
Category :
Keyword :

News Quick Links

	News Central			Health Watch
	Latest Health News			Health In Focus
	News Category (500+)			Breaking Health News
	Popular News			Celebrating Life
	Health News and Press Release			Medindia - Exclusive
	News Photo Gallery			India Special
	News Video Gallery			Lifestyle and Wellness
	News From Other Resources

Multiple Sclerosis

Complete Medindia Resources

News Categories:


»	Trauma Patients Have High Risk of Vitamin D Deficiency

»	Bread and Dinner Rolls Have High Salt Levels: CDC

»	Latest Weight Loss Tip

»	Diabetes Diagnosis Triggers Unhealthy Diet Promotion Charge on US Celebrity Chef

»	Decaffeinated Coffee Could Improve Memory Function
More Diet News

Genetics & Stem Cells Related News
»	Genetics may be Able to Guide Treatment for Tuberculosis	»	Fathers Pass on Heart Disease Risk to Sons Via Genetic Variation on the Y Chromosome
»	Stem Cell Trial for Hearing Loss	»	Traces To Common Birth Defect in Gene Expression Data, Noticed by MassGeneral, Jackson Researchers
»	Reason for the Survival of Bad Immunity Genes	»	Eradicating of Genetic Diseases Perhaps Via 'Designer' Babies of 3 Parents
»	More Accurate Diagnosis of Genetic Mutations Possible Via New Virtual Tool	»	Scientists Identify Gene Related to Fat Preferences in Humans

Read More >>

Accident and Trauma Care Support Group	Acupuncture Support Group	Albinism / Hypopigmentation / Albinos Support Group
Alcohol abuse / Alcohol dependence / Alcoholism Support Group	Aromatherapy Support Group	Avian Influenza / Bird Flu Support Group
Ayurveda Support Group	Benign Prostatic Hyperplasia Support Group	Birth Defects - Metabolic Defects Support Group

Autoimmune Response in Multiple Sclerosis

Medwonders Health Network

Genetics & Stem Cells Related News

Consumers

Medical Professionals

Medical Students

Directories