Asthma Risk Increases With Mutations in Immune Gene

by Rathi Manohar on  July 1, 2010 at 7:31 PM Research News
RSS Email Print This Page Comment
Font : A-A+

A gene that decides the life of certain immune cells mutates in some people who have asthma, according to a new study.
Asthma Risk Increases With Mutations in Immune Gene
Asthma Risk Increases With Mutations in Immune Gene

The gene encodes a protein called Siglec-8 present on the surfaces of a few types of immune cells. Usually they protect the body and keep it healthy, but can cause harm in allergic conditions.

Bruce S. Bochner, director of the Division of Allergy and Clinical Immunology at the Johns Hopkins University School of Medicine, and colleagues found that natural sugar-based molecules in the body coated on the protein causes the immune cells to die.

However, to test whether mutation in the gene could increase the risk for asthma, the team conducted a study wherein they found that rs36498, single nucleotide polymorphisms was associated with a significantly higher susceptibility to asthma.

"Our results suggest these mutations in the Siglec-8 gene may play a role in asthma. It's reasonable to assume that efforts to target Siglec-8 might be able to influence this disease and others associated with eosinophils," says Bochner.

The findings appear in the June European Journal of Human Genetics.

Source: ANI

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Childhood Asthma DNA Finger Printing Asthma Myasthenia Gravis Remedies for Seasonal Allergy Relief McArdle Disease Allergy - Symptom Evaluation Wheezing Churg-Strauss Syndrome Tests for Asthma 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Advertisement
Advertisement

Stay Connected

  • Available on the Android Market
  • Available on the App Store

Facebook

News Category

News Archive