While the immune cells typically attack disease cells and other foreign entities, the T-cells can mistakenly attack healthy stem cells.
"After infusing the mice with T-cells, the T-cells impaired the function of bone marrow mesenchymal stem cells as well as caused osteoclast numbers to increase," he said.
The bone marrow mesenchymal stem cells, or BMMSC, differentiate to become many different cells including osteoblasts, the cells responsible for bone formation.
If this processed is impaired by T-cells, bone formation cannot keep up with bone resorption caused by osteoclasts, and bone mineral density decreases - the hallmark of osteoporosis that leads to skeletal structural deterioration and fractures.
An aspirin regimen has been linked in earlier epidemiological studies to better bone mineral density, but the mechanisms of its interactions in regards to bone health had not yet been studied extensively, Shi said.
Another exciting aspect of the aspirin treatment is that the dose administered to the mice in order to increase their bone mineral density is the same as that of a typical human aspirin regimen when adjusted for body weight differences, he adds.
While the species difference is still a factor, the results are promising.
The study will be published in PLoS ONE.
Source-ANI
RAS/K