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Aspirin Useful in Reducing BP in People With Prehypertension
Data unveiled on May 15 at the American Society of Hypertension's Twenty Third Annual Scientific Meeting and Exposition (ASH 2008) made the revelations.
People with prehypertension (a blood pressure reading between normal and high; when systolic blood pressure is between 120 and 139 or diastolic blood pressure is between 80 and 89 on multiple readings) are at significant risk of hypertension, or consistently high blood pressure-the biggest risk factor for heart disease and stroke, the two leading causes of death in the Western world.
"This is the first study to reveal that taking aspirin before bedtime as opposed to upon waking in the morning is an effective strategy to lower blood pressure and cost effective way to individualize treatment regimes in pre-hypertensive patients," said lead investigator Prof. Ramon C. Hermida, Director of Bioengineering and Chronobiology at the University of Vigo in Spain.
The purposeful timing of medications in order to enhance beneficial outcomes or to avert adverse effects is known as 'chronotherapeutics'.
Although factors influencing why aspirin has an impact on prehypertensive patients in the evening and not the morning are somewhat unclear, researchers indicate that it could be because aspirin slows down the production of hormones and other substances in the body that cause clotting. Many of those are produced while the body is at rest.
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