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Aspirin May Reduce Risk Of Death From Colorectal Cancer
Acetylsalicylic acid (ASA) or Aspirin was developed as a painkiller and marketed as a headache medication or to treat aches and pains. Research has also suggested its regular use may help to prevent colorectal cancer in people at high risk of the disease.
In Wednesdays issue of the Journal of the American Medical Association, Dr. Andrew Chan of Harvard Medical School in Boston and his colleagues reported patients who already have colon cancer may benefit from taking Aspirin along with surgery and chemotherapy.
Regular aspirin use after the diagnosis of colorectal cancer is associated with lower risk of colorectal cancerspecific and overall mortality, especially among individuals with tumors that overexpress COX-2. "Its exciting that an inexpensive, commonly used medication may be of benefit among this group of patients who are worried about having their cancer recur," Chan said.
But ASA didnt work for everyone, he noted. It was most effective in patients with the most common type of tumour which overproduces the COX-2 enzyme.
The finding makes sense, the researchers said, since Aspirin blocks the effects of the enzyme, which is thought to contribute to the progression and spread of tumours.
In the observational study, Chan and his colleagues analyzed data from two large, ongoing studies of health professionals. Researchers tracked 1, 279 men and women with nonmetastatic colorectal cancer who were followed for an average of 12 years.
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