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Artificial Bones That Mimic Natural Counterparts Developed by Scientists
The researchers have revealed that they used skin cells for the purpose.
Writing about their advancement in the Proceedings of the National Academy of Sciences, the researchers have revealed that the artificial bones display a gradual change from bone to softer tissue rather than the sudden shift of previously developed artificial tissue, providing better integration with the body and allowing them to handle weight more successfully.
"One of the biggest challenges in regenerative medicine is to have a graded continuous interface, because anatomically that's how the majority of tissues appear and there are studies that strongly suggest that the graded interface provides better integration and load transfer," said Andres Garcia, professor in the George W. Woodruff School of Mechanical Engineering at the Georgia Institute of Technology.
The researchers were not only able to create artificial bone that melds into softer tissues, but also to implant the technology in vivo for several weeks.
They created the tissue by coating a three-dimensional polymer scaffold with a gene delivery vehicle that encodes a transcription factor known as Runx2.
The team generated a high concentration of Runx2 at one end of the scaffold, and decreased that amount until they ended up with no transcription factor on the other end, resulting in a precisely controlled spatial gradient of Runx2.
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