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Arterial Clotting may be Prevented by Carbon Monoxide

by Rajashri on  June 25, 2009 at 7:39 PM Research News   - G J E 4
 Arterial Clotting may be Prevented by Carbon Monoxide
A new study has shown that carbon monoxide can protect against arterial clotting despite its ill-effects on the rest of the body.

Carbon monoxide is extremely poisonous, and can inhibit the exposure of oxygen, resulting in death.
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However, the researchers have shown that inflamed or injured tissues up regulate heme oxygenase-1 (HO-1), a protein that both protects cells and produces CO, suggesting that low levels of CO may have protective effects.

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During the study, Chen et al examined clotting mechanisms in mice that received arterial transplants.

They found that absence of HO-1 in these mice resulted in significant mortality due to arterial clotting; however, treatment with a CO-releasing molecule both decreased clotting and improved survival.

The researchers concluded that HO-1/CO plays an "important role ...[in] protection against vascular arterial thrombosis in murine aortic allotransplantation."

The study appears in the American Journal of Pathology.

Source: ANI
RAS
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