Arsenic Exposure can Trigger Tumor Growth

by Trilok Kapur on  February 26, 2010 at 11:23 AM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

 Arsenic Exposure can Trigger Tumor Growth
The mechanism by which the environmental toxin arsenic leads to adverse health effects, including bladder cancer, has been discovered by scientists.

"In a collaborative investigation we found that arsenic, at environmentally relevant levels, is capable of activating the Hedgehog pathway and may represent a novel pathway of arsenic-associated diseases, such as bladder cancer," said Margaret R. Karagas, professor in the Department of Community and Family Medicine at Dartmouth Medical School.

"We provide important insight into the etiology of arsenic-induced disease, potentially relevant to the millions of people worldwide who are exposed to arsenic," she added.

While the correlation between exposure to arsenic resulting in human tumors such as those derived from bladder, lung and skin is well established, the molecular mechanisms driving this connection is unclear.

Karagas and colleagues examined the hypothesis that the secreted protein called Hedgehog, a key oncogenic signaling pathway, might be activated by arsenic. Activation might underlie the mechanism by which arsenic acts as a co-carcinogen.

Using experimental data from cell cultures and results of epidemiologic studies, the researchers found that arsenic activates the Hedgehog signaling by decreasing the stability of the repressor form of GLI3, which is one of the transcription factors that regulate Hedgehog activity.

Also, Karagas and colleagues found high levels of arsenic exposure associated with high levels of Hedgehog activity.

These study results are published in Cancer Research, a journal of the American Association for Cancer Research.

Source: ANI
TRI

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Tumor Markers For Cancer Diagnosis and Prognosis Arsenic Poisoning 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive

Loading...