Are Changes in Brain Function in Early HIV Infection an Indicator of Disease Prognosis?

by Kathy Jones on  October 9, 2011 at 7:44 PM AIDS/HIV News
RSS Email Print This Page Comment bookmark
Font : A-A+

During the early stages of human immunodeficiency virus (HIV) infection, measurable changes in brain function and communication between brain regions may be a consequence of virus-induced injury.
 Are Changes in Brain Function in Early HIV Infection an Indicator of Disease Prognosis?
Are Changes in Brain Function in Early HIV Infection an Indicator of Disease Prognosis?

These abnormalities and their implications in disease prognosis are detailed in an article in the groundbreaking new neuroscience journal Brain Connectivity, a bimonthly peer-reviewed journal published by Mary Ann Liebert, Inc.

Diminished cognitive function will develop in about half of individuals infected with HIV, which may include deficits in memory, attention, psychomotor capabilities, or verbal fluency. Evidence of cognitive decline in HIV infection has implications for prognosis, reduced survival time, and increased risk of death.

Xue Wang and colleagues from Northwestern University (Chicago and Evanston, IL) and North Shore University Health System (Evanston), used functional magnetic resonance imaging (fMRI) to obtain blood-oxygen-level-dependent measurements in multiple brain regions that yield information on resting-state brain connectivity. They compared the measurements collected in HIV-infected (less than 1 year) and healthy subjects. The authors report "prominent changes" between the two groups in the functional connectivity of visual networks, which have a role in visuo-motor coordination. Based on these findings, they conclude that functional connectivity measurements may be a useful, noninvasive tool for identifying neurological involvement and central nervous system injury early in the course of HIV infection. The findings from the NIH-funded Chicago Early HIV Infection Study are presented in the article, "Abnormalities in Resting-State Functional Connectivity in Early Human Immunodeficiency Virus Infection."

"These findings indicate that changes in brain function are occurring very early in HIV infection, and subclinical alterations in functional connectivity may reflect vulnerability to cognitive decline," says Ann Ragin, PhD, Principal Investigator and Research Professor, Northwestern University Medical School, Chicago, IL.



Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

Related Links

More News on:

Oral Health And AIDS Parkinsons Disease AIDS/HIV AIDS/HIV - Epidemiology AIDS/HIV - Clinical Features AIDS/HIV - Health Education AIDS/HIV - Prevention And Transmission AIDS / HIV - Treatment AIDS/HIV- Lab Tests and Faqs Parkinsons Disease Surgical Treatment 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive

Loading...