Tiganis sadi that this study is not the first one to suggest that antioxidants can be a negative, for studies in worms have suggested that antioxidants can shorten lifespan, as have some epidemiological studies in humans.
He further noted that other recent studies had indicated that antioxidants might negate the longer-term benefits of exercise training by lowering the activity of certain genes involved in ROS defence.
Tiganis said it would ultimately be important to work out at what stage ROS go from being good to bad.
He suspects it probably depends on the levels and/or the source of their generation. (ROS are generated both on the surfaces of cells and within cells by mitochondria, which convert nutrients such as glucose into energy, he explained.)
Although any health implications of the new findings would require further study, the findings lead Tiganis to suspect it is best not to take daily antioxidant vitamins, especially if one is otherwise healthy.
"Do exercise," he says, as this is a natural source of ROS that may promote insulin action
The study has been published in the journal Cell Metabolism.
Source-ANI
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