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Antioxidants may Raise Diabetes Risk Rather Than Decrease It

by Sreeraman on  October 07, 2009 at 4:44 PM Diabetes News
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Antioxidants may Raise Diabetes Risk Rather Than Decrease It
A new study has shown that low levels of reactive oxygen species (ROS), especially hydrogen peroxide, within cells may actually protect people from diabetes, by improving their ability to respond to insulin signals.


"Our studies indicate that 'physiological' low levels of ROS may promote the insulin response and attenuate insulin resistance early in the progression of type 2 diabetes, prior to overt obesity and hyperglycemia. In a way, we think there is a delicate balance and that too much of a good thing - surprise, surprise - might be bad," said Tony Tiganis, of Monash University in Australia.

During the study, Tiganis' team observed that mice with a deficiency that prevented them from eliminating physiological ROS did not become insulin resistant on a high-fat diet as they otherwise would have.

The researchers said that those health benefits could be attributed to insulin-induced signals, and the uptake of glucose into their muscles.

Upon giving the mice an antioxidant, the researchers observed that those benefits were lost, leaving the animals with more signs of diabetes.

Tiganis said whether antioxidants are ultimately good for people will probably depend on their state of health or disease.

"In the case of early type 2 diabetes and the development of insulin resistance, our studies suggest that antioxidants would be bad for you," the researcher said.

He said that treatments designed to selectively increase ROS in muscle-if they could be devised-could even help in some cases.

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