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Home » Research News

Antibody That Can Neutralize Hepatitis C Virus Given To A Human

by Aruna on August 10, 2009 at 7:32 AM Research News

A volunteer has for the first time received a human monoclonal antibody that can neutralize the Hepatitis C virus (HCV), says research.

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Researchers at MassBiologics of the University of Massachusetts Medical School (UMMS) have revealed that the volunteer received the antibody known as MBL-HCV1 on July 28, as part of a Phase 1 clinical trial.

The researchers also revealed that the study was proceeding, and would eventually involve 30 healthy subjects in a dose-escalation trial expected to conclude later this year.

"We are pleased that this program has now entered the clinical trial phase," said Dr. Donna Ambrosino, executive director of MassBiologics and a professor of Pediatrics at the Medical School.

"This trial will test the safety of the antibody and measure its activity in the subjects. This will help us determine the useful dose and other parameters as we plan for the next step in this program, which will be a Phase 2 study in liver transplant patients," added the expert.

HCV attacks the liver and can eventually lead to liver failure. For the most serious cases of HCV that do not respond to antiviral drugs, liver transplantation is the only option.

Transplantation can be a life-saving treatment, but in nearly all cases the patient's new liver is eventually infected by HCV because the virus remains in the patient's bloodstream during surgery.

The powerful antiviral drugs now used to attack HCV prior to end-stage liver failure are not routinely used during surgery due to the patients' weakened condition and because of the strong medication that must be used to prevent the body from rejecting the new liver.

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Antibody That Can Neutralize Hepatitis C Virus Given To A Human

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