Instead of using mood stabilizers, people suffering from acute mania could be treated more effectively by using anti-psychotic drugs, a new study published in the journal The Lancet reveals.
The study was conducted by researchers from University of Verona and the Oxford University who analyzed data from 68 clinical trials conducted during 1980 to 2010. The researchers observed the effect of using Johnson & Johnson's Risperdal (risperidone), Eli Lilly's Zyprexa (olanzapine) and generic haloperidol in treating acute mania among adults.
On comparing their efficiency in treating acute mania, the researchers found that the three anti-psychotic drugs were more effective than mood stabilizers with haloperidol being the most effective.
"This study shows both statistically and clinically significant differences between treatments of acute mania. In terms of efficacy, haloperidol, risperidone, and olanzapine outperformed other drugs. In terms of drop-outs, olanzapine, risperidone, and quetiapine were better than haloperidol", the researchers wrote.