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Anti- Obesity Drug May Cause Serious Liver Injury

by Aruna on August 28, 2009 at 10:02 AM Obesity News

Whether an anti-obesity drug being sold over the counter may cause liver damage, is being probed by U.S. authorities.

In April, chemists in the UK started selling Orlistat under the brand name Alli, without the need for a prescription.

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Now, over 30 reports linking the drug to serious liver injury are said to have emerged in America.

Manufacturer GlaxoSmithKline, however, insists that there is no evidence the drug caused liver damage.

In six of the cases reported to the U.S. Food and Drug Administration (FDA), patients reportedly went on to develop organ failure.

According to reports, the agency received 32 reports of liver damage between 1999 and 2008, 30 of which occurred outside the US. Twenty-seven of those cases resulted in hospitalization.

The agency is now said to be reviewing the safety of the drug, but stresses no definite association with liver damage has been established at this stage.

It has advised people who used orlistat to seek medical advice if they experience possible symptoms of liver injury, in particular weakness or fatigue, fever, jaundice, or brown urine.

Other symptoms may include abdominal pain, nausea, vomiting, light-colored stools, itching, or loss of appetite.

In the UK, the Medicines and Healthcare products Regulatory Agency (MHRA) reported having received a total of 1,295 suspected adverse drug reaction reports associated with orlistat, including 137 involving suspected liver damage, since it was licensed in 1998.

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Anti- Obesity Drug May Cause Serious Liver Injury

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