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Anti-HIV Topical Gel Protects Against Herpes Virus
The research is the result of an international collaboration between Belgian, Italian and American laboratories; senior authors Prof. Jan Balzarini from the Rega Institute for Medical Research in Belgium, Prof. Carlo-Federico Perno from the University of Rome "Tor Vergata" in Italy and Dr. Leonid Margolis from the National Institute of Child Health and Human Development, Bethesda, MD, USA. Tenofovir works by inhibiting an enzyme that HIV needs to make copies of itself.
The effect of tenofovir gel on HSV was unanticipated because the drug had previously shown very minimal activity against HSV. "We hypothesized that the discrepancy between the earlier reported lack of significant anti-HSV activity and the new data might be explained by the striking differences in drug concentrations between the oral tenofovir delivery system and topical application of the gel," explains Prof. Balzarini.
Prof. Balzarini and colleagues demonstrated in a variety of experimental models that when tenofovir was applied at concentrations similar to those obtained in the gel, the drug had a potent and direct anti-HSV activity. The researchers went on to unravel the molecular mechanism of the anti-HSV activity and found that, like the effect on HIV, tenofovir efficiently inhibits an enzyme needed for herpes viral replication.
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10/22/2011
Shock!!!! My friend who is living with herpes told me a report from CNN said that the world's largest herpes dating and support site MeetHerpes.com which is powered by plenty of fish now has more than 1,560,000 members. Also, more than 80% of members on the site are good looking and sexy.
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